Hospitals were randomly assigned (1:1) to either the One4All intervention or standard of care. The One4All strategy incorporated rapid, point-of-care HIV screening and CD4 counts, and in-parallel viral load testing, to promote fast and complete diagnosis and staging and provide immediate ART to eligible patients.
Patients enrolled in the study had to be 18 years or older and be identified as HIV-reactive during screening in study hospitals, seeking inpatient or outpatient care in a study hospital, and residing in the study catchment area. Between February 2 and November 25, 2014, 478 patients were enrolled: 232 in One4All and 246 in standard of care.
All enrolled patients were assessed for the primary outcome, which was testing completeness within 30 days, defined as completion of three required tests and their post-test counseling. Safety assessments were hospital admissions for the first 90 days and deaths up to 12 months after enrollment.
Findings were as follows:
Conclusions: This study provides strong evidence for the benefits of a patient-centered approach to streamlined HIV testing and treatment that could help China change the trajectory of its HIV epidemic, and help to achieve the goal of an end to AIDS. Taken together with new, strong evidence of the benefits of treating all people with HIV regardless of CD4 level, a patient-centered approach to streamline HIV testing and ART initiation regardless of CD4 count is clearly beneficial.
Find it in the CTN Library: http://ctndisseminationlibrary.org/display/1282.htm