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FDA Overdose Prevention Framework

Publication Date: Sep 09, 2022


screenshot of FDA Overdose Prevention Framework coverThe FDA Overdose Prevention Framework consists of four overarching priorities that align with the U.S. Department of Health & Human Services' Overdose Prevention Strategy to address the public health emergency as it continues to evolve. The overdose crisis is an evolving public health crisis; as such, FDA continues to evaluate our approach and make adjustments according to the latest available science and data.

FDA’s Overdose Prevention Framework Priorities

  • Supporting primary prevention by eliminating unnecessary initial prescription drug exposure and inappropriate prolonged prescribing.  
  • Encouraging harm reduction through innovation and education. 
  • Advancing development of evidence-based treatments for substance use disorders.  
  • Protecting the public from unapproved, diverted, or counterfeit drugs presenting overdose risks.


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