The Rx Drug Abuse & Heroin Summit is the largest national collaboration of professionals from local, state, and federal agencies, business, academia, treatment providers, and allied communities impacted by prescription drug abuse and heroin use. It is the event for decision makers and allied professionals working to address this public health emergency.

The Summit began in 2012 under the leadership of Operation UNITE and U.S. Rep. Harold “Hal” Rogers (KY-5th). Operation UNITE (Unlawful Narcotics Investigations, Treatment and Education, Inc.) was created in 2003 by Congressman Rogers. UNITE is a collaborative model striving to prevent abuse of drugs and facilitate recovery by creating strategic partnerships, providing leadership, promoting education, coordinating treatment, and supporting law enforcement. UNITE serves a 32-county region in southern and eastern Kentucky.

The Summit is now the largest annual gathering for stakeholders to discuss what’s working in prevention and treatment. Notable speakers in past years have included President Donald J. Trump and First Lady Melania Trump in 2019, President Barack Obama in 2016, Congressmen Hal Rogers, Earl "Buddy" Carter, Wm. Lacy Clay and Congresswoman Susan Brooks in 2019, Congressmen Patrick Kennedy and Newt Gingrich in 2017, and President Bill Clinton and Counselor to the President, Kellyanne Conway in 2018.

The Rx Summit is produced by HMP's Psychiatry and Behavioral Health Learning Network, formerly the Institute for the Advancement of Behavioral Healthcare.