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FDA Overdose Prevention Framework

September 9, 2022


screenshot of FDA Overdose Prevention Framework coverThe FDA Overdose Prevention Framework consists of four overarching priorities that align with the U.S. Department of Health & Human Services' Overdose Prevention Strategy to address the public health emergency as it continues to evolve. The overdose crisis is an evolving public health crisis; as such, FDA continues to evaluate our approach and make adjustments according to the latest available science and data.

FDA’s Overdose Prevention Framework Priorities

  • Supporting primary prevention by eliminating unnecessary initial prescription drug exposure and inappropriate prolonged prescribing.  
  • Encouraging harm reduction through innovation and education. 
  • Advancing development of evidence-based treatments for substance use disorders.  
  • Protecting the public from unapproved, diverted, or counterfeit drugs presenting overdose risks.


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