SAMHSA has issued a new advisory on “Cannabidiol (CBD) – Potential Harms, Side Effects, and Unknowns”. This advisory introduces readers to cannabidiol (CBD), how it is derived, and how it differs from delta-9 THC and other cannabinoids. The advisory focuses on the risks and harms of CBD, especially those products sold directly to consumers. This advisory also clarifies common misconceptions about CBD, given its broad availability and marketing for several medical conditions despite limited evidence of efficacy. It is critical that the general public be made aware of the potential harms associated with CBD use, and parents should keep these products out of the hands of their children.