Substance Use Treatment can be complicated by a variety factors due to the severe impact substances have on the body. Patient’s with Co-Occurring disorders, defined here as having a substance use disorder as well as one or more mental health and/or physical health conditions, often require special consideration and unique approaches when planning or delivering care. A critical aspect of the treatment of co-occurring conditions involves identifying all of the complicating variables that require individualization of the treatment plan and additional understanding or specialization by the treatment providers. Co-Occurring disorders are among the most prevalent factors outside of the actual substance that impact the treatment of Substance Use Disorders. Providers need to understand the impact of co-occurring disorders and best practices for integrating treatment approaches for these conditions.