This Lecture Series presentation will focus on understanding the epidemiology of the opioid crisis, as well as the State and local efforts to combat the opioid crisis. Representatives from both the California Department of Public Health and the Los Angeles County Department of Public Health will discuss efforts occurring across the State and County, respectively, to address the emergence of the opioid epidemic. Efforts include establishing a statewide network of community coalitions to comprehensively address the opioid crisis, along with targeted efforts to expand the adoption of safe opioid prescribing, and access to Medications for Addiction Treatment (MAT) and the opioid overdose prevention medication, naloxone.